题目：Nitric Oxide Signaling in Plants-investigation of plant immune system under nitrosative stress and its application to crop
Reactive oxygen and nitrogen intermediates (ROIs and RNIs), respectively, are central features of the plant immune response. S-nitrosylation, the covalent attachment of a nitric oxide (NO) moiety to a protein cysteine thiol to form an S-nitrosothiol (SNO) is rapidly emerging as a prototypic, redox-based post-translational modification during plant immune function. Some recent insights into how ROIs and RNIs are synthesized and how these small, redox active molecules help orchestrate the plant defence response and hypersensitive response will be discussed in the talk. For instance, interestingly, when concentrations of SNO were high, NO function also governed a negative feedback loop limiting the hypersensitive response, mediated by S-nitrosylation of the NADPH oxidase, an Arabidopsis homologous AtRBOHD at Cys 890, abolishing its ability to synthesize ROIs. Accordingly, mutation of Cys 890 compromised S-nitrosothiol-mediated control of AtRBOHD activity, perturbing the magnitude of cell death development. This cysteine is evolutionarily conserved and specifically S-nitrosylated in both human and fly NADPH oxidase, suggesting that this mechanism may govern immune responses in both plants and animals. In addition, our current study to isolate novel nitrosative stress-responsive immune regulators by transcriptomic approach in both Arabidopsis and rice will be introduced.
Yun Byung-Wook博士自2012年受聘国立庆北大学（KyungpookNationalUniversity）农业与生物科学学院应用生物科学学系植物功能基因组学副教授。2008年在爱丁堡大学分子植物科学研究所（Institute of Molecular Plant Sciences, University of Edinburgh, Edinburgh, United Kingdom)完成博士后研究后受聘为该研究所高级研究员，早前曾在韩国生命工学研究院（Korea Research Institute of Bioscience & Biotechnology）作研究员。Yun Byung-Wook教授本科和硕士在国立庆北大学分别攻读乳业科学和牧草生理科学，博士在国立庆北大学和韩国生物科学与生物技术研究所攻读植物生物化学。
Byung-Wook Yun, Michael J. Skelly, Minghui Yin, Manda Yu, Bong-Gyu Mun, Sang-Uk Lee, Adil Hussain, Steven H. Spoel and Gary J. Loake (2016) Nitric oxide and S-nitrosoglutathione function additively during plant immunity.New Phytol.211, 516-26
Q. Muhammad Imran, Noreen Falak, Adil Hussain, Bong-Gyu Mun, Arti Sharma, Sang-Uk Lee, Kyung-Min Kim andByung-Wook Yun(2016) Nitric oxide responsive heavy metal-associated gene AtHMAD1 contributes to development and disease resistance in Arabidopsis thaliana. Frontiers in Plant Science7, Article 1712
Byung-Wook Yun, Michael J. Skelly, Minghui Yin, Manda Yu, Bong-Gyu Mun, Sang-Uk Lee, Adil Hussain, Steven H. Spoel and Gary J. Loake (2016) Nitric oxide and S-nitrosoglutathione function additively during plant immunity. New Phytol.211, 516-26
Home Regina Wacera, Fika Ayu Safitri, Hyun-Suk Lee,Byung-Wook Yun*and Kyung-Min Kim* (2015) Genetic Mapping of QTLs that Control Grain Characteristics in Rice (Oryza sativa L.). J of Life Science25, 925-31 *Corresponding author
Jin Hee Kim, Kyung-Min Kim,Byung-Wook Yun(2015) Establishment of a One-Step Plant Regeneration System in Sweet Potato (Ipomoea batatas[L.] Lam.) Global Journal of Biology, Agriculture & Health Sciences4, 48-55
Ye-Jin Son, Gyu-Ho Lee, Hyun-Suk Lee, Tri Handoyo,Byung-Wook Yun, Kyung-Min Kim (2014) Analysis of High-Resolution QTL Markers Associated with Rice Yields Using Data for Two Consecutive Years in Different Environmental Conditions. Natural Science6, 818-827
Yun, B.-W., Yan, Z., Amir, R., Hong, S.-M., Jin, Y.-W., Lee, E.-K. and Loake, G.J. (2012) Plant natural products: history, limitations and the potential of cambial meristematic cells. Biotechnology & Genetic Engineering Reviews28, 47-59
Byung-Wook Yun, Steven H. Spoel and Gary J. Loake (2012) Synthesis of and signalling by small, redox active molecules in the plant immune response. Biochim Biophys Acta Biochim Biophys Acta1820, 770-776
Yun BW, Feechan A, Yin M, Saidi NB, Le Bihan T, Yu M, Moore JW, Kang JG, Kwon E, Spoel SH, Pallas JA, Loake GJ (2011) S-nitrosylation of NADPH oxidase regulates cell death in plant immunity. Nature478, 264-8
Saad I Malik, Adil Hussain,Byung-Wook Yun, Steven H. Spoel and Gary J. Loake (2011) GSNOR-mediated de-nitrosylation in the plant defence response. Plant Science181, 540-4
Lee EK, Jin YW, Park JH, Yoo YM, Hong SM, Amir R, Yan Z, Kwon E, Elfick A, Tomlinson S, Halbritter F, Waibel T,Yun BW, Loake GJ. (2010) Cultured cambial meristematic cells as a source of plant natural products. Nature Biotechnol.28,1213-7
Mourad A.M. Aboul-Soud, Xinwei Chen, Jeong-Gu Kang,Byung-Wook Yun, Hannah Barton and Gary J. Loake (2009) Activation tagging of ADR2 conveys a spreading lesion phenotype and resistance to biotrophic pathogens. New Phytol.183, 1163-75
Andy R. McLeod, Stephen C. Fry, Gary J. Loake, David J. Messenger, David S. Reay, Keith A. Smith andByung-Wook Yun(2008) Ultraviolet radiation drives methane emissions from terrestrial plant pectins. New phytologist180, 124–132
Pedro Nurmberg , Kirsten Knox ,Byung-Wook Yun, Peter Morris , Reza Shafiei , Andrew Hudson , Gary Loake (2007) The developmental selector AS1 is an evolutionary conserved regulator of the plant immune response. Proc Natl Acad Sci U S A.104, 18795-18800
